Authors: Dr. Yadav Ankita, Dr. Kumari Neelam, Dr. Lamba Neha
DOI Link: https://doi.org/10.22214/ijraset.2024.60732
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I. INTRODUCTION
Our ancient Classics explain Pandu Roga, a sickness where the skin's colour fades and the body loses luster, as "Vaivarnaketekidhulisannibha." The primary diagnostic characteristic of Pandu Roga is the body's color change, or panduvarna(1) (pallor). Pallor, the primary feature of Pandu Roga, can be associated with anemia, which is caused by a reduction in the total amount of red blood cells in circulation and a drop in hemoglobin when compared to normal for that age and gender. The two primary factors that are crucial to the creation of Rakta are Ranjaka Pitta and Rakta Dhatwagni. Regarding its role in coloring rasa and participating in Rakototpatti, Ranjaka Pitta is one of the kinds of pitta that is primarily found in the stomach, liver, and spleen.
According to WHO estimates, around 2 billion people worldwide suffer from anemia, with iron deficiency accounting for about 50% of cases. The frequency of anemia in women between the ages of 15 and 49 is 29.9% worldwide. The prevalence is 36.5% in pregnant women and 29.6% in women of reproductive age who are not pregnant. According to WHO estimates, 40% of pregnant women globally and 42% of children under the age of five are anemic. The prevalence of anemia among children aged 6-59 months is 39.8%. (3) In order to provide a safe and effective treatment, more research is therefore required. 40 patients will get Gudanagaradi Gutika 500 mg BD for thirty days as part of this study. The rooksha, ushna, deepan, and pachan qualities of Gudanagaradi Gutika are beneficial in the production of aampachana and strotovishodhana. Because mandoor bhasma is erythropoietic, it helps in treat iron deficiency anemia by raising hemoglobin levels. This medication was selected for this study. (9)
II. REVIEW OF LITERATURE
All of the traditional Ayurvedic texts, such as Brih-trayi, Laghu-trayi, and Nighantu, in addition to more current textbooks, will be studied. We'll search a variety of websites, including PubMed, Google Scholar, Scopes, Articles, Journals, and Research Papers, for relevant content.
III. MODERN LITERATURE
The prevalence of iron deficiency anemia is high in both urban and rural populations. Iron deficiency anemia (IDA) is frequently caused by a diet low in iron, RBC breakdown, RBC production deficiency, and increased blood loss. (5) Pale skin, weakness, exhaustion, shortness of breath, and other symptoms are among the clinical signs of iron deficiency anemia (IDA). (6) The diagnosis is also predicated on the iron status, bone marrow morphology, and peripheral blood results. Parenteral and oral iron therapy are the mainstays of treatment for iron deficiency anemia. (7)
IV. AYURVEDIC LITERATURE
Acharya Charaka states that the pitta becomes inflamed and enters the Hridaya as a result of the etiological conditions. This inflamed pitta vitiates the Hridaya avasthit sadhaka pitta, which is then caused by vayu to emerge via the dasadhamani and disperse throughout the body. It also acquires sthana sanchaya in between the mansa and twacha, resulting in pandu, haridra, harita varuna, and other manifestations, ultimately leading to Pandu Roga. The body's bala, varna, sneha, and oja are decreased as a result of the Pitta-predominant vata and other doshas vitiating the rakta and other dhatus. As a result, dhatus characteristics diminish, leading to Raktalpata Medalpata, Ojakshrinata, Indriya Saithilya, Nishaar, and Vaivarna, collectively referred to as Pandu Roga. (4)
Drug Review[8,9] –
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This yoga is mentioned in Charak Samhita Chikitsa Sthana 16th chapter, Pandu Roga Chikitsa Adhyaya verse 72 and content of its contents are explained [Table 2]
Method of Prepration of Yoga – This yoga is made as described in the Charaka Samhita in the form of Gutika and is taken with lukewarm water.
V. NEED OF STUDY
VI. SOURCE OF DATA
This clinical study will be carried out on patients thus patients form the material for this study. Total of 40 patients of either sex of age group 25-45 years will be selected randomly from OPD and IPD of Shree Krishna Government Ayurvedic College and Hospital, Kurukshetra, Haryana.
VII. AIMS AND OBJECTIVE
VIII. HYPOTHESIS
A. Inclusion Criteria –
B. Exclusion Criteria –
C. Discontinuation Criteria –
Follow-Up – Throughout treatment, patients will be seen every tenth day to monitor any changes in symptomatology and to determine any complications.
IX. DISCUSSION
Pandu Roga is a disorder characterized by a reduction in body luster and a fading of skin color, primarily due to an exacerbated pitta. This inflamed pitta vitiates the Hridaya avasthit sadhaka pitta, which is then caused by vayu to emerge via the dasadhamani and disperse throughout the body. It also acquires sthana sanchaya in between the mansa and twacha, resulting in pandu, haridra, harita varuna, and other manifestations, ultimately leading to Pandu Roga. The body's bala, varna, sneha, and oja are decreased as a result of the Pitta-predominant vata and other doshas vitiating the rakta and other dhatus. It is comparable to anemia, namely iron deficiency anemia. The rooksha, ushna, deepan, and pachan qualities of Gudanagaradi Gutika are beneficial in the production of aampachana and strotovishodhana. As a result, it aids in balancing doshas and Mandoor Bhasma, which helps treat iron deficiency anemia by raising hemoglobin levels due to its erythropoietic nature. Therefore, it might be really helpful for Pandu sufferers, or as we might say, for individuals with iron deficient anemia.
A. Subjective Criteria
All the Symptoms will be assessed by using the Symptom Rating Scale and these symptoms are-
B. Objective Parameters
Following investigations will be done for safety and efficacy of the drugs and to exclude the cases as per the exclusion criteria mentioned earlier.
X. CRITERIA FOR THE ASSESSMENT OF OVERALL EFFECT OF THE THERAPIES
Clinical parameters measured both before and after the completion of the task will be used to evaluate the outcomes, and additional findings will be assessed using the tabular form. [Table 3].
XI. STATISTICAL ANALYSIS
Based on the aforementioned observations, data will be collected and statistically analyzed using the mean (x), standard deviation (S.D.), and standard error (S.E.). The relevant statistical test that is required will be used. The results acquired will be explained as follows:
• Insignificant - P < 0.10
• Significant - P < 0.05,
• Highly Significant - <0.01 • Highly Significant - P >< 0.001
XII. SUMMARY AND CONCLUSION
After the aforementioned study, the work will be compiled and the outcome will be determined with the use of statistical data.
XIII. ETHICAL CONSIDERATION
The ethical committee has approved the research topic following a thorough review and presentation.
XIV. ASSENT OR CONSENT
In-depth treatment information will be provided to subjects in their mother tongue. Patients will be requested to obtain written consent before the experiment starting.
XV. RESULTS
After being tallied and statistically assessed using relevant tests and the appropriate level of significance, the treatment's outcomes will be reported.
Table 1 : Contents of drug -
Dravya |
Botanical Name |
Part used |
Quantity |
Puran Guda |
Jaggery |
Guda |
1 part |
Mandoor Bhasma |
Ferric oxide |
Bhasma |
1 part |
Sauntha |
Zingiber officinale |
Rhizome |
1 part |
Tila |
Sesanum indicum |
Seed |
1 part |
Pippali |
Piper longum |
Fruit |
2 part |
Table 2: Grading of Blood Hemoglobin Level
Grading |
Male |
Female |
Go- Normal |
Hb>=13 |
Hb >=12 |
G1- Mild Anaemia |
Hb=11-12.9 |
Hb=11-11.9 |
G2-Moderate Anaemia |
Hb=8-10.9 |
Hb=8-10.9 |
G3-Severe Anaemia |
Hb<8 |
Hb<8 |
Table 3 : Result and assessment -
S. No. |
Positive Result Findings |
Assessment |
1. |
Less than 25% |
Non-satisfactory |
2. |
25% to 50% |
Good |
3. |
50% to 75% |
Satisfactory |
4. |
75% to 100% |
Excellent |
Copyright © 2024 Dr. Yadav Ankita, Dr. Kumari Neelam, Dr. Lamba Neha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Paper Id : IJRASET60732
Publish Date : 2024-04-21
ISSN : 2321-9653
Publisher Name : IJRASET
DOI Link : Click Here